Know Your Source: Ethical Considerations in Obtaining 5-MeO-DMT

The sourcing of 5-meo-dmt extracted from the Sonoran Desert Toad is poorly understood and incorrectly reported.  Here, we will try to add our knowledge and experience to the conversation and hopefully teach you some things along the way.

Myth #1-the toad uses the 5-meo-dmt in its glands as a defense mechanism. 

This is not true.  Every single toad collector and sanctuary person we spoke with agreed with this position. 

Members of the Church of the Sacred Synthesis spent part of this recent summer of 2022 on both the Mexican and US sides of the Sonoran Desert.  We worked with a toad Jedi who spent his 6^th season living with the toads in southern Arizona and we visited a toad sanctuary and worked with the Seri people in Mexico using bufo.  We also spoke and worked with numerous toad milkers on the US side including some who had collected medicine in Mexico and who work with a different sanctuary than the one we visited.  

Snakes, Racoons, and birds of prey are the top predators of Bufo Alvarius.  Mammalian brains and retinas make 5-meo-dmt.  Snakes and birds are not affected by 5-meo-dmt since they don’t have it in their biology.  Raccoons have learned to catch the toads by their rear legs and flip them over and eat them from their underside to avoid the glands on the top of their skin. 

Leading Causes of the Decreasing Toad Population

The effects of habitat loss and climate change are immediate threats to the species.  Yet the major reason for the loss of numbers of the toads is the #2 myth-toad aficionados collecting their exudate are the primary cause in the decrease in toad populations.  This is not true.  The primary cause of their decrease is water loss in their natural habitats

Visiting a toad sanctuary on the Mexican side of the Sonoran desert, when you cross the US-Mexico border at the California/Arizona border there is no longer any water flowing in the Colorado River on the Mexican side. The river is the borderline between the two states. We got to enter the Colorado river near the Lake Havasu Reservoir, AZ less than 200 miles north of the US/Mexico border.  Here several large diversions draw from the river, providing water for the Salt River Valley of Arizona and metropolitan Southern California. The last major U.S. diversion is at Imperial Dam, where over 90 percent of the river’s flow is diverted to irrigate California’s Imperial Valley, the most productive winter agricultural region in the United States. 

All of the toads living on the Mexico side of the Colorado River around the banks do not have any livable habitat since there is no river to support them.  The leading threat to the toad’s existence is the lack of water and water table compromise. 

Alternatives to Toad Sourced 5-MeO-DMT

We had a meeting with the CEO and Medical Director of Back Yards Algae Sciences (BYAS) who has successfully reproduced toad parotoid glands and the world’s first known cell-based 5-MeO-DMT, essentially recreating the basic parts of the cell’s structure to carry out the physiological processes of the organism.  I wish we had asked him if robots would actually do the milking of the glands. 

What about bio-reactors producing 5-meo-dmt like Ken Nelson the first human being reported to smoke toad was promoting?  With CRISPR and yeast cultures already making psilocin (4-ho-DMT) it seems like a no-brainer.   Hamilton Morris offered on Vice and in a reprinting of Ken’s book Bufo Alvarius: the Psychedelic Toad of the Sonoran Desert a green synthesis of 5-meo-dmt from mexamine (5-meo-tryptamine).  Mexamine can be synthesized from melatonin (n-acetyl-5-meo-tryptamine) which is available from sustainable plant-based sources.  

Phalaris grass (Phalaris aquatica and Phalaris arundinacea) are viable sources of 5-meo-dmt although some unwanted tryptamines can be present along with the desired molecule.  These can be cleaned up through column chromatography or minimized through selective breeding of cultivars.  There are also other plants with useful enough concentrations of 5-meo-dmt to be viable candidates. 

Toad sanctuaries, bio-reactors, green synthesis, plant-based sources, and lab-grown 5-meo-dmt are all viable solutions for the ethical sourcing of 5-meo-dmt.  What about those who milk the toads in their natural habitat?  We witnessed the ethical milking of toads in the wild and can confirm that it can be done with no harm to the animals and no cross-sharing of potential disease vectors.  We also witnessed humane treatment of the toads at the sanctuary we visited.   

Those who want to consume 5-meo-dmt have lots of options.  If one wants that molecule from toad, no harm toad milking and sanctuary models are available along with lab-grown toad.  If one wants it from plants, green sustainable options are available directly from plants or from precursors that come from plants. If one wants it from the fungal kingdom, kombucha cultures are toad ally viable.  

Our advice: Know your Source and invest in procurement that sustains ethical practices and fair trade for those harvesting or growing your medicine.